Stress activation of mesocorticolimbic dopamine neurons: effects of a glycine/NMDA receptor antagonist.

@article{Morrow1993StressAO,
  title={Stress activation of mesocorticolimbic dopamine neurons: effects of a glycine/NMDA receptor antagonist.},
  author={B A Chris Morrow and William A. Clark and Robert H. Roth},
  journal={European journal of pharmacology},
  year={1993},
  volume={238 2-3},
  pages={
          255-62
        }
}
Restraint of brief duration causes a metabolic activation of mesocortical and some mesolimbic dopaminergic systems with little effect on the nigrostriatal system. We have examined the ability of an antagonist of the allosteric glycine site of the N-methyl-D-aspartate receptor complex to block the stress-induced response in dopamine utilization. Thirty minutes of restraint stress elevated dopamine metabolism, as measured by the ratio between 3,4-dihydroxyphenylacetic acid (DOPAC) and dopamine… CONTINUE READING
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