Stress-System Genes and Life Stress Predict Cortisol Levels and Amygdala and Hippocampal Volumes in Children

@article{Pagliaccio2014StressSystemGA,
  title={Stress-System Genes and Life Stress Predict Cortisol Levels and Amygdala and Hippocampal Volumes in Children},
  author={David Pagliaccio and Joan L. Luby and Ryan Bogdan and Arpana Agrawal and Michael S. Gaffrey and Andrew C. Belden and Kelly N. Botteron and Michael P. Harms and Deanna M. Barch},
  journal={Neuropsychopharmacology},
  year={2014},
  volume={39},
  pages={1245-1253}
}
Depression has been linked to increased cortisol reactivity and differences in limbic brain volumes, yet the mechanisms underlying these alterations are unclear. One main hypothesis is that stress causes these effects. This is supported by animal studies showing that chronic stress or glucocorticoid administration can lead to alterations in hippocampal and amygdala structures. Relatedly, life stress is cited as one of the major risk factors for depression and candidate gene studies have related… CONTINUE READING
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Introduction to Mediation, Moderation, and Conditional Process Analysis

  • AF Hayes
  • Guilford Press.
  • 2013
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