Stress-Induced Mutagenesis and Complex Adaptation

@article{Ram2014StressInducedMA,
  title={Stress-Induced Mutagenesis and Complex Adaptation},
  author={Yoav Ram and Lilach Hadany},
  journal={bioRxiv},
  year={2014}
}
Because mutations are mostly deleterious, mutation rates should be reduced by natural selection. However, mutations also provide the raw material for adaptation. Therefore, evolutionary theory suggests that the mutation rate must balance between adaptability – the ability to adapt – and adaptedness – the ability to remain adapted. We model an asexual population crossing a fitness valley and analyze the rate of complex adaptation with and without stress-induced mutagenesis – the increase of… 
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