Stress Impairs GABAergic Network Function in the Hippocampus by Activating Nongenomic Glucocorticoid Receptors and Affecting the Integrity of the Parvalbumin-Expressing Neuronal Network

@article{Hu2010StressIG,
  title={Stress Impairs GABAergic Network Function in the Hippocampus by Activating Nongenomic Glucocorticoid Receptors and Affecting the Integrity of the Parvalbumin-Expressing Neuronal Network},
  author={Wen Hu and Mingyue Zhang and Boldizs{\'a}r Cz{\'e}h and Gabriele Fl{\"u}gge and Weiqi Zhang},
  journal={Neuropsychopharmacology},
  year={2010},
  volume={35},
  pages={1693-1707}
}
Stress facilitates the development of psychiatric disorders in vulnerable individuals. It affects physiological functions of hippocampal excitatory neurons, but little is known about the impact of stress on the GABAergic network. Here, we studied the effects of stress and a synthetic glucocorticoid on hippocampal GABAergic neurotransmission and network function focusing on two perisomatic interneurons, the parvalbumin (PV)- and the cholecystokinin (CCK)-positive neurons. In acute hippocampal… CONTINUE READING

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