Stress Hormone Epinephrine Enhances Adipogenesis in Murine Embryonic Stem Cells by Up-Regulating the Neuropeptide Y System

@article{Han2012StressHE,
  title={Stress Hormone Epinephrine Enhances Adipogenesis in Murine Embryonic Stem Cells by Up-Regulating the Neuropeptide Y System},
  author={R. Han and Joanna B Kitlinska and William R. Munday and G. I. Gallicano and Z. Żukowska},
  journal={PLoS ONE},
  year={2012},
  volume={7}
}
  • R. Han, Joanna B Kitlinska, +2 authors Z. Żukowska
  • Published 2012
  • Biology, Medicine
  • PLoS ONE
  • Prenatal stress, psychologically and metabolically, increases the risk of obesity and diabetes in the progeny. However, the mechanisms of the pathogenesis remain unknown. In adult mice, stress activates NPY and its Y2R in a glucocorticoid-dependent manner in the abdominal fat. This increased adipogenesis and angiogenesis, leading to abdominal obesity and metabolic syndrome which were inhibited by intra-fat Y2R inactivation. To determine whether stress elevates NPY system and accelerates… CONTINUE READING
    23 Citations
    Effects of Neuropeptide Y on Stem Cells and Their Potential Applications in Disease Therapy
    • 11
    • PDF
    Hypothalamus-adipose tissue crosstalk: neuropeptide Y and the regulation of energy metabolism
    • 76
    • PDF
    AIMP1 negatively regulates adipogenesis by inhibiting PPAR&ggr;
    • 3
    • PDF
    Role of maternal nutrition in programming adiposity in the offspring: potential implications of glucocorticoids
    • C. Breton
    • Biology, Medicine
    • Hormone molecular biology and clinical investigation
    • 2013
    • 2

    References

    SHOWING 1-10 OF 61 REFERENCES
    Neuropeptide Y is produced in visceral adipose tissue and promotes proliferation of adipocyte precursor cells via the Y1 receptor
    • 134
    TSH stimulates adipogenesis in mouse embryonic stem cells.
    • 40
    • PDF
    PBX1: A Novel Stage‐Specific Regulator of Adipocyte Development
    • 27
    Minireview: Pref-1: role in adipogenesis and mesenchymal cell fate.
    • H. Sul
    • Biology, Medicine
    • Molecular endocrinology
    • 2009
    • 196
    • PDF
    Secretion of neuropeptide Y in human adipose tissue and its role in maintenance of adipose tissue mass.
    • 54
    • PDF
    Stress‐induced changes in epinephrine expression in the adrenal medulla in vivo
    • 44
    Differentiation of embryonic stem cells into adipocytes in vitro.
    • 431
    • PDF