Stress Granules and Virus Replication.

  title={Stress Granules and Virus Replication.},
  author={C Lindsay Miller},
  journal={Future virology},
  volume={6 11},
Viruses are dependent on the cellular translation machinery for protein synthesis. Part of the innate immune response to infection is activation of the stress kinase PKR which phosphorylates the alpha subunit of the initiation factor eIF2. This results in inhibition of translation and is intended to block virus replication. A downstream effect of translational shutoff involves the formation of cytoplasmic granules, termed stress granules (SGs), that contain mRNAs, initiation factors, ribosomal… CONTINUE READING