Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

@article{Brunet2004StressDependentRO,
  title={Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase},
  author={Anne Brunet and Lora B. Sweeney and J. F. Sturgill and Katrin F Chua and Paul L Greer and Yingxi Lin and Hien G. Tran and Sarah E. Ross and Raul Mostoslavsky and Haim Y Cohen and Linda S. Hu and Hwei-Ling Cheng and Mark P. Jedrychowski and Steven P. Gygi and David A. Sinclair and Frederick W. Alt and Michael Eldon Greenberg},
  journal={Science},
  year={2004},
  volume={303},
  pages={2011 - 2015}
}
The Sir2 deacetylase modulates organismal life-span in various species. However, the molecular mechanisms by which Sir2 increases longevity are largely unknown. We show that in mammalian cells, the Sir2 homolog SIRT1 appears to control the cellular response to stress by regulating the FOXO family of Forkhead transcription factors, a family of proteins that function as sensors of the insulin signaling pathway and as regulators of organismal longevity. SIRT1 and the FOXO transcription factor… 
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TLDR
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TLDR
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Regulation of FOXOs and p53 by SIRT1 Modulators under Oxidative Stress
TLDR
The results indicate that FOXO1, FOXO3a and FOXO4, are indispensable for Sirt1-dependent cell survival against oxidative stress, although deacetylation of p53 has also some role for cell protective function of SIRT1.
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