Stress‐induced modulation of the immune response to recombinant hepatitis B vaccine.

  title={Stress‐induced modulation of the immune response to recombinant hepatitis B vaccine.},
  author={Ronald Glaser and J. K. Kiecolt-Glaser and Robert H. Bonneau and William B. Malarkey and Susan E. Kennedy and James Hughes},
  journal={Psychosomatic Medicine},
&NA; Each of a series of three hepatitis B (Hep B) inoculations was given to 48 second‐year medical students on the 3rd day of a 3‐day examination series to study the effect of academic stress on the ability to generate an immune response to a primary antigen. Those students who seroconverted after the first injection (25%) were significantly less stressed and anxious than those who did not seroconvert at that time. In addition, students who reported greater social support demonstrated a… 

The Influence of Psychological Stress on the Immune Response to Vaccines a

The differences in antibody and T‐cell responses to HEP‐B and influenza virus vaccinations provide a demonstration of how stress may be able to alter both the cellular and humoral immune responses to vaccines and novel pathogens in both younger and older adults.

Modulation of immune response to rDNA hepatitis B vaccination by psychological stress.

Disclosure of trauma and immune response to a hepatitis B vaccination program.

The finding that a writing intervention influences immune response provides further support for a link between emotional disclosure and health.

Stressor-Induced Alterations of Adaptive Immunity to Vaccination and Viral Pathogens

Rate of Acquired Immunity in Dental Students after Hepatitis B Vaccination

There was a considerable rate of failure in achieving or maintaining acceptable titer levels following routine vaccination against HBV, Hence, determining serum anti-HBs titer after vaccination is recommended.

Chronic restraint stress induces severe disruption of the T‐cell specific response to tetanus toxin vaccine

A decrease in cytokine production with relevant antigen (interferon‐γ and interleukin‐10), without a T helper type 1 and 2 secretion imbalance is reported, and an alteration in the humoral response is observed, including a delay in isotype maturation and an immunoglobulin G1/G2a imbalance.

Perceived Stress and Psychological Well-Being Are Associated With Antibody Status After Meningitis C Conjugate Vaccination

Evidence is provided that antibody status after a conjugate vaccination may be susceptible to psychological influences, and high perceived stress, but not life events stress, was associated with low antibody titers.

Vaccine-Induced Anti-HBs Level in 5-6 Year-Old Malnourished Children

It is concluded that severity of malnutrition does not affect vaccine-induced antibody level and seroprotection rate; however small sample size in each group of study hinders decisive conclusion.

Vaccine-induced antibody responses as parameters of the influence of endogenous and environmental factors.

It has been suggested that antibody responses to vaccination might be useful in this context, and there is good evidence that smoking, diet, psychological stress, and certain infectious diseases affect vaccination titers, although it is difficult to determine to what extent.



Stress-related immune suppression: Health implications

Psychosocial Modifiers of Immunocompetence in Medical Students

Blood was drawn twice from 75 first‐year medical students, with a baseline sample taken one month before their final examinations and a stress sample drawn on the first day of final examinations to address the effects of a naturally occurring stressor on components of the immune response.

Psychosocial Risk Factors in the Developmental of Infectious Mononucleosis*

The combination of high motivation and poor academic performance interacted in predicting clinical IM, and it was revealed that these two additional indices of infection or illness could also be predicted from the same set of psychosocial risk factors.

Psychological and neuroendocrine measures related to functional immune changes in anticipation of HIV‐1 serostatus notification.

Results indicated that cortisol levels were elevated at study entry and decreased across the subsequent five‐week period—mirroring the changes in mitogen responsivity across these timepoints—and Persisting intrusive thoughts about risk of HIV‐1 infectivity (after seronegativity notification) were consistently associated with higher plasma cortisol levels.

Suppression of lymphocyte stimulation following bereavement.

In a prospective study of 15 spouses of women with advanced breast carcinoma, lymphocyte stimulation responses to phytohemagglutinin, concanavalin A, and pokeweed mitogen were significantly

Changes in immune and psychological measures as a function of anticipation and reaction to news of HIV‐1 antibody status.

The findings suggested that asymptomatic HIV‐1 infected individuals may be unable to mount an immune response to potent psychosocial stressors (i.e., serostatus notification), due perhaps, to the fact that the viral contribution to immune functioning overrides any influence of environmental stimuli.

Nutrition, Immunity, and Infection: Mechanisms of Interactions

I welcome the privilege of writing some words of introduction to this important book. Its authors have been courageous in bringing together in one text a triad of topics that cover such large tracts

Psychological and immunological predictors of genital herpes recurrence.

A model is proposed linking depressive mood, CD8+ cells, and HSV recurrence, and subjects with high levels of depressive mood who did not report many symptoms of other infections had a higher rate of HSV Recurrence.

Stress-induced modulation of the immune response.

Both the blastogenic activity of concanavalin A or lipopolysaccharide and the ability of immune lymphocytes to lyse P815 target cells showed the same patterns of immunosuppression and enhancement.

Reduced serum antibodies associated with social defeat in rats