Stress‐associated H3K4 methylation accumulates during postnatal development and aging of rhesus macaque brain

@article{Han2012StressassociatedHM,
  title={Stress‐associated H3K4 methylation accumulates during postnatal development and aging of rhesus macaque brain},
  author={Yixing Han and Dali Han and Zheng Yan and Jerome D. Boyd-Kirkup and Christopher D. Green and Philipp Khaitovich and Jing-Dong J. Han},
  journal={Aging Cell},
  year={2012},
  volume={11}
}
Epigenetic modifications are critical determinants of cellular and developmental states. Epigenetic changes, such as decreased H3K27me3 histone methylation on insulin/IGF1 genes, have been previously shown to modulate lifespan through gene expression regulation. However, global epigenetic changes during aging and their biological functions, if any, remain elusive. Here, we examined the histone modification H3K4 dimethylation (H3K4me2) in the prefrontal cortex of individual rhesus macaques at… Expand
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