Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects.

@article{Mahar2014StressSA,
  title={Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects.},
  author={Ian Mahar and Francis Rodriguez Bambico and Naguib Mechawar and Jos{\'e} N. Nobrega},
  journal={Neuroscience and biobehavioral reviews},
  year={2014},
  volume={38},
  pages={173-92}
}
Chronic stressful life events are risk factors for developing major depression, the pathophysiology of which is strongly linked to impairments in serotonin (5-HT) neurotransmission. Exposure to chronic unpredictable stress (CUS) has been found to induce depressive-like behaviours, including passive behavioural coping and anhedonia in animal models, along with many other affective, cognitive, and behavioural symptoms. The heterogeneity of these symptoms represents the plurality of corticolimbic… CONTINUE READING