Stress, genes and the mechanism of programming the brain for later life

@article{Kloet2005StressGA,
  title={Stress, genes and the mechanism of programming the brain for later life},
  author={Edo Ronald de Kloet and Rosana M. Sibug and Frans M. Helmerhorst and Mathias V. Schmidt},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2005},
  volume={29},
  pages={271-281}
}

Plasticity of the epigenome during early-life stress.

Maternal separation in the rat : long-term effects of early life events on emotionality, drug response and neurobiology

The results do not provide support for the suggestion that MS manipulations causes enhanced anxiety or disruptions in endocrinology and neurochemistry in the adult rat, and could reflect a parallel to human conditions as relatively good psychosocial functioning is sometimes seen despite serious adverse experiences in childhood.

Age- and Sex-Dependent Effects of Early Life Stress on Hippocampal Neurogenesis

The data show that neurogenesis is affected by early life stress in an age- and sex-dependent manner and that normalization may be possible during critical stages of brain development.

Early-life adversity programs emotional functions and the neuroendocrine stress system: the contribution of nutrition, metabolic hormones and epigenetic mechanisms*

Evidence that exposure to both early- life stress and early-life under-/malnutrition similarly lead to life-long alterations on the neuroendocrine stress system and modify emotional functions is reviewed.

Pre- and post-natal stress programming : from genes to physiology

The results of this thesis suggest that early life stress can trigger both transient and permanent physiological changes, depending on the sex and the quality of both the pre- and post-hatching environment.

Early life stress and hippocampal neurogenesis in the neonate: sexual dimorphism, long term consequences and possible mediators

The immediate and late effects of early life stress on hippocampal neurogenesis in male and female rat pups are summarized, its later consequences in emotionality are compared, and some relevant mediator peptides that could be potentially involved in programming are highlighted.
...

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