Stress, Adaptation, and Disease: Allostasis and Allostatic Load

  title={Stress, Adaptation, and Disease: Allostasis and Allostatic Load},
  author={Bruce Mcewen},
  journal={Annals of the New York Academy of Sciences},
  • Bruce Mcewen
  • Published 1 May 1998
  • Biology, Psychology
  • Annals of the New York Academy of Sciences
Abstract: Adaptation in the face of potentially stressful challenges involves activation of neural, neuroendocrine and neuroendocrine‐immune mechanisms. This has been called “allostasis” or “stability through change” by Sterling and Eyer (Fisher S., Reason J. (eds): Handbook of Life Stress, Cognition and Health. J. Wiley Ltd. 1988, p. 631), and allostasis is an essential component of maintaining homeostasis. When these adaptive systems are turned on and turned off again efficiently and not too… 

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