Streptozotocin-induced diabetes progressively increases blood-brain barrier permeability in specific brain regions in rats.

@article{Huber2006StreptozotocininducedDP,
  title={Streptozotocin-induced diabetes progressively increases blood-brain barrier permeability in specific brain regions in rats.},
  author={Jason Delwyn Huber and Reyna L. Vangilder and Kimberly A Houser},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2006},
  volume={291 6},
  pages={H2660-8}
}
This study investigated the effects of streptozotocin-induced diabetes on the functional integrity of the blood-brain barrier in the rat at 7, 28, 56, and 90 days, using vascular space markers ranging in size from 342 to 65,000 Da. We also examined the effect of insulin treatment of diabetes on the formation and progression of cerebral microvascular damage and determined whether observed functional changes occurred globally throughout the brain or within specific brain regions. Results… CONTINUE READING
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