Streptozotocin-induced diabetes increases gamma-glutamyltranspeptidase activity but not expression in rat liver.

@article{Watkins1998StreptozotocininducedDI,
  title={Streptozotocin-induced diabetes increases gamma-glutamyltranspeptidase activity but not expression in rat liver.},
  author={John B. Watkins and James E Klaunig and H. Gregory Smith and Paul Cornwell and Ruth A. Sanders},
  journal={Journal of biochemical and molecular toxicology},
  year={1998},
  volume={12 4},
  pages={219-25}
}
Earlier work describing increased biliary excretion of the acetaminophen-cysteine conjugate advanced the hypothesis that streptozotocin-induced diabetes increases gamma-glutamyltranspeptidase (GGT) expression in Sprague-Dawley rats. To test this hypothesis, rats were divided into control, diabetic, and insulin-treated diabetic groups. Diabetes was induced by intravenous injection of 45 mg streptozotocin/kg body weight and was effectively controlled by insulin treatment in the appropriate group… CONTINUE READING