Streptozotocin-induced diabetes enhances cardiac heparin-releasable lipoprotein lipase activity in spontaneously hypertensive rats.

@article{Shepherd1998StreptozotocininducedDE,
  title={Streptozotocin-induced diabetes enhances cardiac heparin-releasable lipoprotein lipase activity in spontaneously hypertensive rats.},
  author={G. R. Shepherd and Margaret C. Cam and Nandakumar Sambandam and Mohammed A Abrahani and Brian Rodrigues},
  journal={Hypertension},
  year={1998},
  volume={31 3},
  pages={878-84}
}
Vascular endothelial-bound lipoprotein lipase (LPL), also known as heparin-releasable LPL, catalyzes the breakdown of the triglyceride component of lipoproteins and is rate-limiting for free fatty acid transport to tissues. We previously demonstrated that heparin-releasable LPL activity increases in diabetic Wistar rat hearts, whereas with the development of hypertension in spontaneously hypertensive rats (SHR), there is a concomitant and progressive reduction in LPL activity. The objective of… CONTINUE READING

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