Streptozotocin-induced diabetes differentially affects sympathetic innervation and control of plantar metatarsal and mesenteric arteries in the rat.

@article{Johansen2013StreptozotocininducedDD,
  title={Streptozotocin-induced diabetes differentially affects sympathetic innervation and control of plantar metatarsal and mesenteric arteries in the rat.},
  author={Niloufer J. Johansen and Diana Tripovic and James A Brock},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2013},
  volume={304 2},
  pages={
          H215-28
        }
}
In humans neural control of arterial vessels supplying skin in the extremities is particularly vulnerable to the effects of diabetes. Here the streptozotocin (STZ) rat model of type 1 diabetes was used to compare effects on neurovascular function in plantar metatarsal arteries (PMAs), which supply blood to skin of hind paw digits, with those in mesenteric arteries (MAs). Twelve weeks after STZ (60 mg/kg ip), wire myography was used to assess vascular function. In PMAs, lumen dimensions were… CONTINUE READING

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