Streptozotocin at low doses induces apoptosis and at high doses causes necrosis in a murine pancreatic beta cell line, INS-1.

@article{Saini1996StreptozotocinAL,
  title={Streptozotocin at low doses induces apoptosis and at high doses causes necrosis in a murine pancreatic beta cell line, INS-1.},
  author={Kulvinder Singh Saini and Cole D. Thompson and C M Winterford and Neal I. Walker and Donald P Cameron},
  journal={Biochemistry and molecular biology international},
  year={1996},
  volume={39 6},
  pages={1229-36}
}
The ability of beta cells to endure assaults by various environmental agents, including toxins and viruses, may be relevant to the development of diabetes. We have examined the mode of cell death caused by streptozotocin (STZ) in a murine pancreatic beta cell line, INS-1. Apoptosis was identified by detection of initial endonuclease-mediated DNA strand… CONTINUE READING