Streptozotocin, but not alloxan, induces DNA repair synthesis in mouse pancreatic islets in vitro

  title={Streptozotocin, but not alloxan, induces DNA repair synthesis in mouse pancreatic islets in vitro},
  author={Stellan Sandler and Ingemar Swenne},
In the present investigation, the abilities of streptozotocin and alloxan to induce DNA repair synthesis in isolated mouse pancreatic islets have been compared using an autoradiographic technique. Streptozotocin exposure in vitro induced a dose-dependent DNA repair synthesis, whereas no such effect was observed after alloxan treatment. The hydroxyl radical scavenger dimethyl urea and the poly(ADP-ribose) synthetase inhibitors nicotinamide and theophylline reduced the streptozotocin-induced DNA… CONTINUE READING
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