Streptozotocin, but not alloxan, induces DNA repair synthesis in mouse pancreatic islets in vitro

@article{Sandler1983StreptozotocinBN,
  title={Streptozotocin, but not alloxan, induces DNA repair synthesis in mouse pancreatic islets in vitro},
  author={Stellan Sandler and Ingemar Swenne},
  journal={Diabetologia},
  year={1983},
  volume={25},
  pages={444-447}
}
In the present investigation, the abilities of streptozotocin and alloxan to induce DNA repair synthesis in isolated mouse pancreatic islets have been compared using an autoradiographic technique. Streptozotocin exposure in vitro induced a dose-dependent DNA repair synthesis, whereas no such effect was observed after alloxan treatment. The hydroxyl radical scavenger dimethyl urea and the poly(ADP-ribose) synthetase inhibitors nicotinamide and theophylline reduced the streptozotocin-induced DNA… CONTINUE READING
19 Citations
28 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 28 references

Effects of nicotinamide on alloxan and streptozotocin induced mouse pancreatic B cell cytotoxicity in vivo and in vitro

  • S Sandler, M Welsh
  • Diabetologia
  • 1982
2 Excerpts

In vitro effects of streptozotocin (SZ) on (pro)insulin biosynthesis, contents of adenine and pyridine nucleotides and oxygen uptake in mouse pancreatic islets

  • S Sandler, M Welsh
  • Acta Endocrinol
  • 1982
1 Excerpt

Protective role of superoxide dismutase against diabetogenic drugs

  • SM Gaudy, MG Buse, RK Crouch
  • J Clin Invest
  • 1982
1 Excerpt

Action of toxic drugs on islet cells

  • SJ Cooperstein, D Watkins
  • 1981
1 Excerpt

Similar Papers

Loading similar papers…