Streptozotocin, Type I Diabetes Severity and Bone

  title={Streptozotocin, Type I Diabetes Severity and Bone},
  author={Katherine J Motyl and Laura R McCabe},
  booktitle={Biological Procedures Online},
As many as 50% of adults with type I (T1) diabetes exhibit bone loss and are at increased risk for fractures. Therapeutic development to prevent bone loss and/or restore lost bone in T1 diabetic patients requires knowledge of the molecular mechanisms accounting for the bone pathology. Because cell culture models alone cannot fully address the systemic/metabolic complexity of T1 diabetes, animal models are critical. A variety of models exist including spontaneous and pharmacologically induced T1… CONTINUE READING
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2007)Histomorphometric analysis of diabetic osteopenia in streptozotocin-induced diabetic mice: a possible role of oxidative stress

  • Y Hamada
  • Bone
  • 2007