Streptozocin-induced diabetic rats: behavioural evidence for a model of chronic pain

@article{Courteix1993StreptozocininducedDR,
  title={Streptozocin-induced diabetic rats: behavioural evidence for a model of chronic pain},
  author={Christine Courteix and Alain Eschalier and Jeannine Lavarenne},
  journal={Pain},
  year={1993},
  volume={53},
  pages={81-88}
}
Painful diabetic neuropathy is one of the most common complications of insulin-dependent diabetes in man. Conflicting results have been obtained in experimentally diabetic animals subjected to pain stimuli. This work aimed to systematically study the response of rats made diabetic (hyperglycemia > or = 14 mM) by injection of streptozocin (STZ) (75 mg/kg, i.p.), to various pain stimuli: mechanical, thermal (warm and cold) and chemical. The time course of the scores was followed for 4 weeks… CONTINUE READING

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