Streptokinase entrapment in interdigitation-fusion liposomes improves thrombolysis in an experimental rabbit model.

@article{Perkins1997StreptokinaseEI,
  title={Streptokinase entrapment in interdigitation-fusion liposomes improves thrombolysis in an experimental rabbit model.},
  author={Walter R. Perkins and Douglas E. Vaughan and S R Plavin and William L. Daley and Joyce Rauch and L Lee and Andrew S. Janoff},
  journal={Thrombosis and haemostasis},
  year={1997},
  volume={77 6},
  pages={1174-8}
}
The successful design of new thrombolytic agents depends on providing these agents with increased clot selectivity. As recently demonstrated (10), entrapment of tissue plasminogen activator into liposomes apparently provided the selective targeting needed to improve the efficacy of this fibrinolytic agent. To test whether liposomal entrapment would benefit streptokinase, a fibrinolytic agent with a different mode of action and inactivation, we compared liposomal streptokinase with free… CONTINUE READING

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