Streptococcus suis serotype 2, an important swine and human pathogen, induces strong systemic and cerebral inflammatory responses in a mouse model of infection.

@article{DomnguezPunaro2007StreptococcusSS,
  title={Streptococcus suis serotype 2, an important swine and human pathogen, induces strong systemic and cerebral inflammatory responses in a mouse model of infection.},
  author={Mar{\'i}a C Dom{\'i}nguez-Punaro and M. Garcia Segura and Marie-Mich{\`e}le Plante and Sonia Lacouture and Serge Rivest and Marcelo Gottschalk},
  journal={Journal of immunology},
  year={2007},
  volume={179 3},
  pages={
          1842-54
        }
}
Streptococcus suis, an important swine and human pathogen, causes septic shock and meningitis. The pathogenesis of both systemic and CNS infections caused by S. suis is poorly understood. A hematogenous model of infection in CD1 mice was developed to study the systemic release of cytokines during the septic shock phase and the proinflammatory events in the CNS associated with this pathogen. Using a liquid array system, high levels of systemic TNF-alpha, IL-6, IL-12, IFN-gamma, CCL2, CXCL1, and… CONTINUE READING

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Up - regulation of ICAM - 1 , CD 11 a / CD 18 and CD 11 c / CD 18 on human THP - 1 monocytes stimulated by Streptococcus suis serotype 2

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