Streptococcus pyogenes nuclease A (SpnA) mediated virulence does not exclusively depend on nuclease activity.

@article{Chalmers2017StreptococcusPN,
  title={Streptococcus pyogenes nuclease A (SpnA) mediated virulence does not exclusively depend on nuclease activity.},
  author={Callum Chalmers and Adrina Hema J. Khemlani and Chae Ryeong Sohn and Jacelyn M S Loh and Catherine Jia-Yun Tsai and Thomas Proft},
  journal={Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi},
  year={2017}
}
BACKGROUND Streptococcus pyogenes, or Group A Streptococcus (GAS), is a human pathogen that causes a wide range of diseases, including pharyngitis, necrotizing fasciitis and toxic shock syndrome. The bacterium produces a large arsenal of virulence factors, including the cell wall-anchored Streptococcus pyogenes nuclease A (SpnA), which facilitates immune evasion by degrading the DNA backbone of neutrophil extracellular traps. SpnA consists of a C-terminal endo/exonuclease domain and a N… CONTINUE READING
BETA

Similar Papers

Loading similar papers…