Streptococcus pyogenes cytolysin-mediated translocation does not require pore formation by streptolysin O.

@article{Magassa2010StreptococcusPC,
  title={Streptococcus pyogenes cytolysin-mediated translocation does not require pore formation by streptolysin O.},
  author={N'Goundo Magassa and Sukantha Chandrasekaran and Michael G Caparon},
  journal={EMBO reports},
  year={2010},
  volume={11 5},
  pages={400-5}
}
Bacterial toxin injection into the host cell is required for the virulence of numerous pathogenic bacteria. Cytolysin-mediated translocation (CMT) of Streptococcus pyogenes uses streptolysin O (SLO) to translocate the S. pyogenes nicotinamide adenine dinucleotide-glycohydrolase (SPN) into the host cell cytosol, resulting in the death of the host cell. Although SLO is a pore-forming protein, previous studies have shown that pore formation alone is not sufficient for CMT to occur. Thus, the role… CONTINUE READING
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