Streptococcus pyogenes activates human plasmacytoid and myeloid dendritic cells.

  title={Streptococcus pyogenes activates human plasmacytoid and myeloid dendritic cells.},
  author={Ville Veckman and Ilkka Julkunen},
  journal={Journal of leukocyte biology},
  volume={83 2},
Human peripheral blood contains two major dendritic cell (DC) populations, namely CD11c(-)CD123+ plasmacytoid DCs (PDCs) and CD11c+CD123(-) myeloid DCs (MDCs). Although the activation of these DC types by various TLR ligands has been relatively well-characterized, less is known about the ability of whole live bacteria to induce PDC and MDC activation. In the present report, we have compared the activation of human PDCs and MDCs in response to major human bacterial pathogen Streptococcus… CONTINUE READING

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