Streptococcus pyogenes CovRS mediates growth in iron starvation and in the presence of the human cationic antimicrobial peptide LL-37.

@article{Froehlich2009StreptococcusPC,
  title={Streptococcus pyogenes CovRS mediates growth in iron starvation and in the presence of the human cationic antimicrobial peptide LL-37.},
  author={Barbara J Froehlich and Christopher Bates and June R. Scott},
  journal={Journal of bacteriology},
  year={2009},
  volume={191 2},
  pages={673-7}
}
We found that the global regulatory two-component signal transduction system CovRS mediates the ability of group A streptococcus (GAS) to grow under two stresses encountered during infection: iron starvation and the presence of LL-37. We also showed that CovRS regulates transcription of the multimetal transporter operon that is important for GAS growth in a low concentration of iron. 

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