Streptococcus pneumoniae sheds syndecan-1 ectodomains through ZmpC, a metalloproteinase virulence factor.

@article{Chen2007StreptococcusPS,
  title={Streptococcus pneumoniae sheds syndecan-1 ectodomains through ZmpC, a metalloproteinase virulence factor.},
  author={Ye Chen and Atsuko Hayashida and Allison E Bennett and Susan K. Hollingshead and Pyong Woo Park},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 1},
  pages={159-67}
}
Several microbial pathogens stimulate the ectodomain shedding of host cell surface proteins to promote their pathogenesis. We reported previously that Pseudomonas aeruginosa and Staphylococcus aureus activate the ectodomain shedding of syndecan-1 and that syndecan-1 shedding promotes P. aeruginosa pathogenesis in mouse models of lung and burned skin infections. However, it remains to be determined whether activation of syndecan-1 shedding is a virulence mechanism broadly used by pathogens. Here… CONTINUE READING
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