Streptococcus pneumoniae secretes hydrogen peroxide leading to DNA damage and apoptosis in lung cells.

@article{Rai2015StreptococcusPS,
  title={Streptococcus pneumoniae secretes hydrogen peroxide leading to DNA damage and apoptosis in lung cells.},
  author={Prashant M. Rai and Marcus C Parrish and Ian Jun Jie Tay and Na Li and Shelley Ackerman and Fang He and Jimmy Kwang and Vincent T. K. Chow and Bevin P. Engelward},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 26},
  pages={E3421-30}
}
Streptococcus pneumoniae is a leading cause of pneumonia and one of the most common causes of death globally. The impact of S. pneumoniae on host molecular processes that lead to detrimental pulmonary consequences is not fully understood. Here, we show that S. pneumoniae induces toxic DNA double-strand breaks (DSBs) in human alveolar epithelial cells, as indicated by ataxia telangiectasia mutated kinase (ATM)-dependent phosphorylation of histone H2AX and colocalization with p53-binding protein… CONTINUE READING
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