Streptococcus pneumoniae pep27 mutant as a live vaccine for serotype-independent protection in mice.

@article{Kim2012StreptococcusPP,
  title={Streptococcus pneumoniae pep27 mutant as a live vaccine for serotype-independent protection in mice.},
  author={Eun-Hye Kim and Sang-Yoon Choi and Min-Kyoung Kwon and Thao Dang-Hien Tran and Sang-Sang Park and Kwang-Jun Lee and Song-Mee Bae and David E. Briles and Dong-Kwon Rhee},
  journal={Vaccine},
  year={2012},
  volume={30 11},
  pages={2008-19}
}
Streptococcus pneumoniae (pneumococcus) is responsible for significant morbidity and mortality in worldwide. After introduction of current pneumococcal vaccines, a marked decrease in the incidence of pneumococcal disease was observed. Unfortunately, serotype shifts in carriage and disease, including capsular switch and presence of antimicrobial resistance, have been found. Here we report live attenuated vaccine strain which is avirulent and can protect from systemic and mucosal pneumococcal… CONTINUE READING

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