Streptococcus pneumoniae damages the ciliated ependyma of the brain during meningitis.

  title={Streptococcus pneumoniae damages the ciliated ependyma of the brain during meningitis.},
  author={Robert A Hirst and Bejal Gosai and Andrew Rutman and P. W. Andrew and Christopher O'callaghan},
  journal={Infection and immunity},
  volume={71 10},
Streptococcus pneumoniae meningitis remains a disease with a poor outcome for the patient. A region of the brain that has been neglected in the study of meningitis is the ependyma, which has been identified as a location of adult pluripotent cells. In this study we have used a rat model of meningitis to examine whether the ependymal layer is affected by S. pneumoniae. The effects included localized loss of cilia, a decrease of the overall ependymal ciliary beat frequency, and damage to the… CONTINUE READING
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NOTES 6099 at U nirsity of Leester on N ovem er 21

  • R. A. Hirst, K. S. Sikand, A. Rutman, T. J. Mitchell, P. W. Andrew
  • Infect. Immun
  • 2003
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