Streptococcus pneumoniae capsular serotype 19F is more resistant to C3 deposition and less sensitive to opsonophagocytosis than serotype 6B.

@article{Melin2009StreptococcusPC,
  title={Streptococcus pneumoniae capsular serotype 19F is more resistant to C3 deposition and less sensitive to opsonophagocytosis than serotype 6B.},
  author={Merit M Melin and Hanna Jarva and Lotta Siira and Seppo Meri and Helena M K{\"a}yhty and Merja V{\"a}kev{\"a}inen},
  journal={Infection and immunity},
  year={2009},
  volume={77 2},
  pages={
          676-84
        }
}
The polysaccharide capsule is a major virulence mechanism of Streptococcus pneumoniae, shielding the bacterium from phagocytes. Capsule types may differ in their abilities to resist immune defense. Antibody-mediated complement activation and opsonophagocytosis are crucial in protection against pneumococcus. Conjugate vaccine trials suggest imperfect protection against 19F. We have previously shown that significantly more anti-19F than anti-6B antibody is needed for killing in the… CONTINUE READING

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