Streptococcus pneumoniae-associated human macrophage apoptosis after bacterial internalization via complement and Fcgamma receptors correlates with intracellular bacterial load.

@article{Ali2003StreptococcusPH,
  title={Streptococcus pneumoniae-associated human macrophage apoptosis after bacterial internalization via complement and Fcgamma receptors correlates with intracellular bacterial load.},
  author={Farzana Ali and Margaret E. Lee and Francesco Iannelli and Gianni Pozzi and Tim J Mitchell and Robert C Read and David H Dockrell},
  journal={The Journal of infectious diseases},
  year={2003},
  volume={188 8},
  pages={1119-31}
}
Opsonization enhances Streptococcus pneumoniae-induced human monocyte-derived macrophage (MDM) apoptosis. Both depletion of complement and immunoglobulin from opsonizing serum and blockade of the macrophages CR1, CR3, FcgammaRII, and FcgammaRIII partially decreased MDM apoptosis after S. pneumoniae phagocytosis, and these effects correlated with reduced numbers of internalized bacteria. Chloramphenicol inhibition of protein synthesis by opsonized S. pneumoniae down-regulated subsequent MDM… CONTINUE READING