Streptococcus pneumoniae Translocates into the Myocardium and Forms Unique Microlesions That Disrupt Cardiac Function

@inproceedings{Brown2014StreptococcusPT,
  title={Streptococcus pneumoniae Translocates into the Myocardium and Forms Unique Microlesions That Disrupt Cardiac Function},
  author={Armand O. Brown and Beth H Mann and Geli Gao and Jane S Hankins and Jessica Humann and Jonathan Giardina and Paola Faverio and Marcos I Restrepo and Ganesh V. Halade and Eric M Mortensen and Merry L Lindsey and Martha A. Hanes and Kyle I. Happel and Steve Nelson and Gregory J. Bagby and Jose A. Lorent and Pablo Cardinal and Rosario Granados and Andr{\'e}s Esteban and Claude J. LeSaux and Elaine I Tuomanen and Carlos J Orihuela and Michael R. Wessels},
  booktitle={PLoS pathogens},
  year={2014}
}
Hospitalization of the elderly for invasive pneumococcal disease is frequently accompanied by the occurrence of an adverse cardiac event; these are primarily new or worsened heart failure and cardiac arrhythmia. Herein, we describe previously unrecognized microscopic lesions (microlesions) formed within the myocardium of mice, rhesus macaques, and humans during bacteremic Streptococcus pneumoniae infection. In mice, invasive pneumococcal disease (IPD) severity correlated with levels of serum… CONTINUE READING