Streptococcus pneumoniae R6 interspecies transformation: genetic analysis of penicillin resistance determinants and genome-wide recombination events.

@article{Sauerbier2012StreptococcusPR,
  title={Streptococcus pneumoniae R6 interspecies transformation: genetic analysis of penicillin resistance determinants and genome-wide recombination events.},
  author={Julia Sauerbier and Patrick Maurer and Martin Rieger and Regine Hakenbeck},
  journal={Molecular microbiology},
  year={2012},
  volume={86 3},
  pages={
          692-706
        }
}
Interspecies gene transfer has been implicated as the major driving force for the evolution of penicillin resistance in Streptococcus pneumoniae. Genomic alterations of S. pneumoniae R6 introduced during four successive transformations with DNA of the high-level penicillin-resistant Streptococcus mitis B6 with beta-lactam selection have now been determined and the contribution of genes to high resistance levels was analysed genetically. Essential for high level resistance to penicillins of the… CONTINUE READING
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