Streptococcus mutans extracellular DNA is upregulated during growth in biofilms, actively released via membrane vesicles, and influenced by components of the protein secretion machinery.

@article{Liao2014StreptococcusME,
  title={Streptococcus mutans extracellular DNA is upregulated during growth in biofilms, actively released via membrane vesicles, and influenced by components of the protein secretion machinery.},
  author={Sumei Liao and Marlise In{\^e}z Klein and Kyle P Heim and Yuwei Fan and J P Bitoun and San-Joon Ahn and Robert A Burne and Hyun Koo and L. Jeannine Brady and Zezhang T Wen},
  journal={Journal of bacteriology},
  year={2014},
  volume={196 13},
  pages={2355-66}
}
Streptococcus mutans, a major etiological agent of human dental caries, lives primarily on the tooth surface in biofilms. Limited information is available concerning the extracellular DNA (eDNA) as a scaffolding matrix in S. mutans biofilms. This study demonstrates that S. mutans produces eDNA by multiple avenues, including lysis-independent membrane vesicles. Unlike eDNAs from cell lysis that were abundant and mainly concentrated around broken cells or cell debris with floating open ends… CONTINUE READING
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