Streptococcus iniae phosphoglucomutase is a virulence factor and a target for vaccine development.

@article{Buchanan2005StreptococcusIP,
  title={Streptococcus iniae phosphoglucomutase is a virulence factor and a target for vaccine development.},
  author={John T. Buchanan and Jason A. Stannard and Xavier Lauth and Vaughn E. Ostland and Henry C. Powell and Mark E. Westerman and Victor Nizet},
  journal={Infection and immunity},
  year={2005},
  volume={73 10},
  pages={6935-44}
}
Streptococcus iniae represents a major health and economic problem in fish species worldwide. Random Tn917 mutagenesis and high-throughput screening in a hybrid striped bass (HSB) model of meningoencephalitis identified attenuated S. iniae mutants. The Tn917 insertion in one mutant disrupted an S. iniae homologue of a phosphoglucomutase (pgm) gene. Electron microscopy revealed a decrease in capsule thickness and cell wall rigidity, with DeltaPGM mutant cells reaching sizes approximately 3-fold… CONTINUE READING

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