Streptococcal pyrogenic exotoxin B-induced apoptosis in A549 cells is mediated through alpha(v)beta(3) integrin and Fas.

@article{Tsai2008StreptococcalPE,
  title={Streptococcal pyrogenic exotoxin B-induced apoptosis in A549 cells is mediated through alpha(v)beta(3) integrin and Fas.},
  author={Wan-Hua Tsai and Chia-Wen Chang and Y S Lin and W L Chuang and Jiunn-Jong Wu and C A Liu and P L Tsai and Ming Te Lin},
  journal={Infection and immunity},
  year={2008},
  volume={76 4},
  pages={1349-57}
}
Our previous work suggested that streptococcal pyrogenic exotoxin (SPE) B-induced apoptosis is mediated through a receptor-like mechanism. In this study, we have identified alpha(v)beta(3) and Fas as the SPE B receptors for this function. The SPE B fragment without the RGD motif and G308S, a SPE B mutant with the RSD motif, induced less apoptosis than did native SPE B, suggesting that the RGD motif is critical for SPE B-induced apoptosis. Fluorescein isothiocyanate-SPE B binding assays and… CONTINUE READING
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