Streptococcal mimicry and antibody-mediated cell signaling in the pathogenesis of Sydenham's chorea.

@article{Kirvan2006StreptococcalMA,
  title={Streptococcal mimicry and antibody-mediated cell signaling in the pathogenesis of Sydenham's chorea.},
  author={Christine A Kirvan and Susan E. Swedo and David K. Kurahara and Madeleine W. Cunningham},
  journal={Autoimmunity},
  year={2006},
  volume={39 1},
  pages={21-9}
}
Recent evidence suggests that the pathogenesis of Sydenham's chorea following group A streptococcal infection is due to antibodies which develop due to the infection and infiltrate the brain and basal ganglia. Antibodies present in acute chorea react with the surface of neuronal cells and signal the induction of calcium calmodulin dependent protein kinase II with elevation of tyrosine hydroxylase and subsequent dopamine release which may lead to the movement disorder. The antibodies present in… CONTINUE READING

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