Streptococcal inhibitor of complement promotes innate immune resistance phenotypes of invasive M1T1 group A Streptococcus.

Abstract

Streptococcal inhibitor of complement (SIC) is a highly polymorphic extracellular protein and putative virulence factor secreted by M1 and M57 strains of group A Streptococcus (GAS). The sic gene is highly upregulated in invasive M1T1 GAS isolates following selection of mutations in the covR/S regulatory locus in vivo. Previous work has shown that SIC… (More)
DOI: 10.1159/000317672

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@article{Pence2010StreptococcalIO, title={Streptococcal inhibitor of complement promotes innate immune resistance phenotypes of invasive M1T1 group A Streptococcus.}, author={Morgan A Pence and Suzan H. M. Rooijakkers and Anna L. Cogen and Jason N. S. Cole and Andrew Hollands and Richard L Gallo and Victor Nizet}, journal={Journal of innate immunity}, year={2010}, volume={2 6}, pages={587-95} }