Streptococcal cell wall-induced arthritis: requirements for IL-4, IL-10, IFN-gamma, and monocyte chemoattractant protein-1.

@article{Schimmer1998StreptococcalCW,
  title={Streptococcal cell wall-induced arthritis: requirements for IL-4, IL-10, IFN-gamma, and monocyte chemoattractant protein-1.},
  author={Ralph C. Schimmer and Denis J. Schrier and Craig M. Flory and K D Laemont and Daniel KL Tung and Alan L. Metz and Hans Peter Friedl and M. C. Conroy and Jeffrey S. Warren and Beatrice Beck and Peter A Ward},
  journal={Journal of immunology},
  year={1998},
  volume={160 3},
  pages={1466-71}
}
Intra-articular injection of streptococcal cell wall Ag followed by i.v. challenge ("reactivation") results in a destructive lymphocyte-dependent monoarticular arthritis. To further define the role of immune mechanisms in the model, Abs to Th1 and Th2-related cytokines were evaluated. Treatment of rats with antibodies to IL-4 reduced swelling, while treatment with anti-IL-10 or anti-IFN-gamma either had no effect or slightly enhanced the inflammatory response. These results suggest that Th-2… CONTINUE READING

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