Streptococcal R plasmid pIP501: endonuclease site map, resistance determinant location, and construction of novel derivatives.

@article{Evans1983StreptococcalRP,
  title={Streptococcal R plasmid pIP501: endonuclease site map, resistance determinant location, and construction of novel derivatives.},
  author={R. P. Evans and Francis L. Macrina},
  journal={Journal of bacteriology},
  year={1983},
  volume={154 3},
  pages={1347-55}
}
The streptococcal resistance plasmid pIP501 (30 kilobase pairs [kb]) encodes resistance to chloramphenicol (Cmr) and erythromycin (Emr) and is capable of conjugative transfer among numerous streptococcal species. By using a streptococcal host-vector recombinant DNA system, the Cmr and Emr determinants of pIP501 were localized to 6.3-kb HindIII and 2.1-kb HindIII-AvaI fragments, respectively. pIP501 was lost at a frequency of 22% in Streptococcus sanguis cells grown at 42 degrees C but was… CONTINUE READING

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