Streptococcal M protein size mutants occur at high frequency within a single strain

@article{Fischetti1986StreptococcalMP,
  title={Streptococcal M protein size mutants occur at high frequency within a single strain},
  author={Vincent A. Fischetti and M Jarymowycz and Kevin F. Jones and June R. Scott},
  journal={The Journal of Experimental Medicine},
  year={1986},
  volume={164},
  pages={971 - 980}
}
Streptococcal M protein, the antiphagocytic molecule on the surface of the organism, was previously found to exhibit extensive size heterogeneity between as well as within M serotypes. In this study, methods were devised to isolate M protein size mutants within a laboratory-grown culture. We were able to isolate three independent M protein deletion mutants and one additional mutant, which was derived from the first deletion mutant. We found that these deletion mutants occur at a frequency of… CONTINUE READING