Strengths and limitations of using repeat-dose toxicity studies to predict effects on fertility.

@article{Dent2007StrengthsAL,
  title={Strengths and limitations of using repeat-dose toxicity studies to predict effects on fertility.},
  author={Matthew P Dent},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2007},
  volume={48 3},
  pages={241-58}
}
  • Matthew P Dent
  • Published 2007 in Regulatory toxicology and pharmacology : RTP
The upcoming European chemicals legislation REACH (Registration, Evaluation, and Authorisation of Chemicals) will require the risk assessment of many thousands of chemicals. It is therefore necessary to develop intelligent testing strategies to ensure that chemicals of concern are identified whilst minimising the testing of chemicals using animals. Xenobiotics may perturb the reproductive cycle, and for this reason several reproductive studies are recommended under REACH. One of the endpoints… CONTINUE READING

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