Strengths and Limitations of Model Systems for the Study of Urinary Tract Infections and Related Pathologies

@article{Barber2016StrengthsAL,
  title={Strengths and Limitations of Model Systems for the Study of Urinary Tract Infections and Related Pathologies},
  author={Amelia E. Barber and J. Paul Norton and Travis J. Wiles and Matthew A Mulvey},
  journal={Microbiology and Molecular Biology Reviews},
  year={2016},
  volume={80},
  pages={351 - 367}
}
SUMMARY Urinary tract infections (UTIs) are some of the most common bacterial infections worldwide and are a source of substantial morbidity among otherwise healthy women. UTIs can be caused by a variety of microbes, but the predominant etiologic agent of these infections is uropathogenic Escherichia coli (UPEC). An especially troubling feature of UPEC-associated UTIs is their high rate of recurrence. This problem is compounded by the drastic increase in the global incidence of antibiotic… 
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TLDR
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TLDR
Comparison of transcriptomic and phenotypic analyses revealed that the expression of key conserved functions during culture could be used to predict subsequent colonization of the mouse bladder, and suggested that UTI risk and outcome may be determined by complex interactions between host susceptibility and the urovirulence potential of diverse bacterial strains.
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TLDR
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TLDR
Critical gaps in understanding of the pathogenic and non-pathogenic colonization of UPEC in different habitats in the host are detailed and a new perspective on UTI susceptibility is described that better reflects the complexity of this disease.
Invasion of Host Cells and Tissues by Uropathogenic Bacteria.
TLDR
The mechanisms and consequences of host cell invasion by uropathogenic bacteria are reviewed, with consideration of the defenses that are brought to bear against facultative intracellular pathogens within the urinary tract.
Vaginal Inoculation of Uropathogenic Escherichia coli during Estrus Leads to Genital and Renal Colonization
TLDR
It is suggested that estrogen primes the urogenital tract to create a conducive milieu for UPEC colonization, and vaginal inoculation of UPEC in mice during estrus represents a novel approach to investigate infection of the kidneys and genital tract and systemic dissemination from the urogensital tract.
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