Strength of the Calpha H..O hydrogen bond of amino acid residues.

@article{Scheiner2001StrengthOT,
  title={Strength of the Calpha H..O hydrogen bond of amino acid residues.},
  author={Steve Scheiner and Tapas Kar and Y. Gu},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 13},
  pages={9832-7}
}
Although the peptide C(alpha)H group has historically not been thought to form hydrogen bonds within proteins, ab initio quantum calculations show it to be a potent proton donor. Its binding energy to a water molecule lies in the range between 1.9 and 2.5 kcal/mol for nonpolar and polar amino acids; the hydrogen bond (H-bond) involving the charged lysine residue is even stronger than a conventional OH..O interaction. The preferred H-bond lengths are quite uniform, about 3.32 A. Formation of… CONTINUE READING

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