Strength of linkage disequilibrium between two vitamin D receptor markers in five ethnic groups: implications for association studies.

@article{Ingles1997StrengthOL,
  title={Strength of linkage disequilibrium between two vitamin D receptor markers in five ethnic groups: implications for association studies.},
  author={Sue Ann Ingles and Robert W Haile and Brian E. Henderson and Laurence N. Kolonel and G Nakaichi and Christina Y Shi and Mimi C. Yu and R K Ronald K Ross and Gerhard A. Coetzee},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={1997},
  volume={6 2},
  pages={93-8}
}
Markers in the 3' end of the vitamin D receptor gene have recently been associated with prostate cancer risk. To evaluate the adequacy of the commonly used BsmI restriction fragment length polymorphism as a marker of this locus, we genotyped 627 individuals from five ethnic groups for this marker, as well as for a polymorphic site in the 3' untranslated region of this gene. At the latter site, we identified 12 alleles, A13 to A24, of a poly(A) microsatellite. Allele size followed a bimodal… CONTINUE READING
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