Strength of integration of transmembrane alpha-helical peptides in lipid bilayers as determined by atomic force spectroscopy.

@article{Ganchev2004StrengthOI,
  title={Strength of integration of transmembrane alpha-helical peptides in lipid bilayers as determined by atomic force spectroscopy.},
  author={Dragomir N. Ganchev and Dirk T. S. Rijkers and M M E Margot M E Snel and J. Antoinette Killian and Ben de Kruijff},
  journal={Biochemistry},
  year={2004},
  volume={43 47},
  pages={14987-93}
}
In this study we address the stability of integration of proteins in membranes. Using dynamic atomic force spectroscopy, we measured the strength of incorporation of peptides in lipid bilayers. The peptides model the transmembrane parts of alpha-helical proteins and were studied in both ordered peptide-rich and unordered peptide-poor bilayers. Using gold-coated AFM tips and thiolated peptides, we were able to observe force events which are related to the removal of single peptide molecules out… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Similar Papers

Loading similar papers…