Streamlining IRB review in multisite trials through single-study IRB Cooperative Agreements: experience of the Beta-Carotene and Retinol Efficacy Trial (CARET).

@article{Thornquist2002StreamliningIR,
  title={Streamlining IRB review in multisite trials through single-study IRB Cooperative Agreements: experience of the Beta-Carotene and Retinol Efficacy Trial (CARET).},
  author={Mark Thornquist and Cim Edelstein and Gary E. Goodman and Gilbert S. Omenn},
  journal={Controlled clinical trials},
  year={2002},
  volume={23 1},
  pages={80-6}
}
With their extensive data and specimen repositories, clinical trials are a long-term, valuable resource to health researchers. However, assuring protection of participants' rights can be challenging, particularly when such trials are conducted at multiple sites with multiple Institutional Review Boards (IRBs). One little-used mechanism that can streamline IRB review in multisite trials while maintaining participants' protections is the single-study IRB Cooperative Agreement. This agreement is… CONTINUE READING