Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema

@article{Jungersted2010StratumCL,
  title={Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema},
  author={Jakob Mutanu Jungersted and Heide Scheer and Martin Mempel and Hansj{\"o}rg Baurecht and Liliana Cifuentes and Julie K. H{\o}gh and Lars Ingvar Hellgren and G. B. Jemec and Tove Agner and Stephan Weidinger},
  journal={Allergy},
  year={2010},
  volume={65}
}
To cite this article: Jungersted JM, Scheer H, Mempel M, Baurecht H, Cifuentes L, Høgh JK, Hellgren LI, Jemec GBE, Agner T, Weidinger S. Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema. Allergy 2010; 65: 911–918. 
Ethnicity and stratum corneum ceramides
TLDR
This work has shown that the altered lipid profile in patients with atopic eczema is driven by the environment, and the influence of environment and genes needs to be explored.
Severe skin inflammation and filaggrin mutation similarly alter the skin barrier in patients with atopic dermatitis
TLDR
Filaggrin deficiency is a well‐known predisposing factor for the development of atopic dermatitis (AD), but some recent data seem to contradict these associations.
Enhancement of stratum corneum lipid structure improves skin barrier function and protects against irritation in adults with dry, eczema‐prone skin *
The skin of patients with atopic dermatitis is characterized by abnormal stratum corneum lipid levels. Consequently, the lamellar matrices are disrupted and skin barrier function is diminished,
Skin reaction and regeneration after single sodium lauryl sulfate exposure stratified by filaggrin genotype and atopic dermatitis phenotype
Filaggrin is key for the integrity of the stratum corneum. Mutations in the filaggrin gene (FLGnull) play a prominent role in atopic dermatitis (AD) pathogenesis. People with AD have increased
Lipid to protein ratio plays an important role in the skin barrier function in patients with atopic eczema
TLDR
It was recently shown that changes in SC lipid composition and organization play a role in the reduced skin barrier in AE, and common mutations in the filaggrin gene strongly predispose for AE.
Eczema and ceramides: an update
TLDR
This review is an update on research indexed in PubMed following the discovery of the filaggrin mutations in atopic dermatitis in 2006, but when newer publications cannot stand alone, it includes publications from before 2006.
Stratum Corneum Lipids and Filaggrin
TLDR
Stratum corneum, the most upper layer of the skin, plays a key role for the skin barrier function and is influenced by pH due to the various pH optima of the different enzymes involved.
Skin Barrier Function and mRNA Expression Profiles in Patients with Atopic Dermatitis, Ichthyosis Vulgaris, and X-linked Recessive Ichthyosis : Aetiopathogenic Differences and the Impact of Moisturizing Treatment
Atopic dermatitis (AD), ichthyosis vulgaris (IV), and X-linked recessive ichthyosis (XLRI) are characterized by dry skin and impaired skin barrier. AD and IV are related to loss-of-function mutatio
Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity
TLDR
Levels of filag Grin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity, and these levels are likely to vary according to the patient’s age and severity.
Distinct barrier integrity phenotypes in filaggrin‐related atopic eczema following sequential tape stripping and lipid profiling
TLDR
There is limited data on the permeability barrier function in filaggrin‐AD under compromised conditions, and the barrier characteristics in FLG mutation carriers under baseline conditions have been investigated.
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