Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: a multicentre international study.

@article{Trivedi2016StratificationOH,
  title={Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: a multicentre international study.},
  author={P J Trivedi and Willem J. Lammers and Henk R van Buuren and Albert Pares and Annarosa Floreani and Harry L. A. Janssen and Pietro Invernizzi and Pier Maria Battezzati and Cyriel Y. Ponsioen and Christophe Corpechot and Raoul Poupon and Marlyn J. Mayo and Andrew K. Burroughs and Frederik Nevens and Andrew L. Mason and Kris V. Kowdley and Ana Lleo and Llorenç Caballer{\'i}a and Keith D Lindor and Bettina E Hansen and Gideon M. Hirschfield},
  journal={Gut},
  year={2016},
  volume={65 2},
  pages={321-9}
}
OBJECTIVE Hepatocellular carcinoma (HCC) is an infrequent yet critical event in primary biliary cirrhosis (PBC); however, predictive tools remain ill-defined. Our objective was to identify candidate risk factors for HCC development in patients with PBC. DESIGN Risk factor analysis was performed in over 15 centres from North America and Europe spanning >40 years observation period using Cox proportional hazards assumptions, logistic regression, and Kaplan-Meier estimates. RESULTS Of 4565… CONTINUE READING

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De fi ning optimal laboratory response criteria in UDCA treated primary biliary cirrhosis . Results of an international multicenter long - term follow - up study

WJ Lammers, H VanBuuren, A Pares
Hepatology • 2013

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